【发现蛋白翻译重编程的“新劳力”】7月29日，在发表于Cell杂志的一项研究中，https://t.cn/A6aD55uP杜克大学 董欣年团队揭示了分子模式激活的免疫反应（PTI）信号通路中一个全新的蛋白翻译起始模块——PABP/R-motif介导的非帽结构依赖的胁迫相关蛋白的翻译。这一发现为真核生物蛋白翻译重编程提供了不同于经典的eIF2a磷酸化通路的理论模型。

Reconstructive ladder - local flap - Limberg flap

In plastic surgery, there are similar answers to many questions - only in different dimensions.

Here we used a Limberg flap to cover a semi-malignant skin cancer, a squamous cell carcinoma, after securing the tumour-free margins.

This is a so-called random pattern flap because the blood supply does not depend on a defined vessel. In that case it would be an axial pattern flap.

The drawings come from Ian T Jackson‘s magnificent book: Local flaps in head and neck surgery.
#医学生Medic[超话]##medicaltalks#

A squamous-cell lung carcinoma developing in the bronchius

Squamous-cell carcinoma of the lung is a histologic type of non-small-cell lung carcinoma (NSCLC). It is the second most prevalent type of lung cancer after lung adenocarcinoma and it originates in the bronchi. Its tumor cells are characterized by a squamous appearance, similar to the one observed in epidermal cells. Squamous-cell carcinoma of the lung is strongly associated with tobacco smoking, more than any other forms of NSCLC.

#医学生Medic[超话]##medicaltalks#