#全国爱耳日#耳机已经成为很多人生活中不可或缺的单品。作为科技领域的佼佼者，有一说一，华为的音频产品做得确实不错，旗下的华为FreeClip耳夹耳机、华为智能眼镜 2、华为FreeBuds Pro 3、华为FreeBuds 5等几款产品，在设计选材、佩戴体验上追求卓越，打造出最为贴合的耳机产品。在服务方面，华为持续为用户带来免费耳机清洁与保养、《健康用耳》华为大讲堂等一系列专属服务，可以说是下足了功夫来守护用户的听觉健康！ #经常用耳机的3个60原则#
cGAS-STING for immunotherapy
- drug development of CDNs and CDN derivatives is challenged by their limited biostability, difficult formulation, poor pharmacokinetics, and inefficient tissue accumulation and cytosolic delivery
- delivery methods: (PLA-b-PEG) micelles for c-di-GMP (CDG) (+PD-1 for B16F10 melanoma); in situ cross-linking endosomolytic polymersomes formed by (DBP-b-PEG) showed great efficiency for cGAMP cytosolic delivery via endosomal escape
- Novel cGAS Agonists for Cancer Immunotherapy: Svg3
- Potential therapeutic target for autoimmune disease: overactivation of the cGAS-STING pathway in humans has been linked to autoimmune diseases including AGS, RA, and SLE. "To suppress the overly strong proinflammatory responses associated with cGAS-STING overactivation in some of the autoimmune disorders, we devised nanomedicine-in-hydrogel (NiH) that codelivers a cGAS inhibitor (RU.521) and cell-free DNA (cfDNA)-scavenging cationic nanoparticles (cNPs) for systemic immunosuppression in rheumatoid arthritis (RA) therapy." --> cRNPs accumulated in draining lymph nodes and captured extracellular/internalized immunostimulatory DNA by cNPs while pharmacologically inhibiting cGAS by RU.521, resulting in decreased production of pro-inflammatory cytokines and reduced expression of costimulatory factors, both of which are essential to present antigens from APCs to naïve T or B cells to elicit antigen-specific effector T or B cells.
ref:
https://t.cn/A6YRU2vH#
https://t.cn/A6YRU2vT
- drug development of CDNs and CDN derivatives is challenged by their limited biostability, difficult formulation, poor pharmacokinetics, and inefficient tissue accumulation and cytosolic delivery
- delivery methods: (PLA-b-PEG) micelles for c-di-GMP (CDG) (+PD-1 for B16F10 melanoma); in situ cross-linking endosomolytic polymersomes formed by (DBP-b-PEG) showed great efficiency for cGAMP cytosolic delivery via endosomal escape
- Novel cGAS Agonists for Cancer Immunotherapy: Svg3
- Potential therapeutic target for autoimmune disease: overactivation of the cGAS-STING pathway in humans has been linked to autoimmune diseases including AGS, RA, and SLE. "To suppress the overly strong proinflammatory responses associated with cGAS-STING overactivation in some of the autoimmune disorders, we devised nanomedicine-in-hydrogel (NiH) that codelivers a cGAS inhibitor (RU.521) and cell-free DNA (cfDNA)-scavenging cationic nanoparticles (cNPs) for systemic immunosuppression in rheumatoid arthritis (RA) therapy." --> cRNPs accumulated in draining lymph nodes and captured extracellular/internalized immunostimulatory DNA by cNPs while pharmacologically inhibiting cGAS by RU.521, resulting in decreased production of pro-inflammatory cytokines and reduced expression of costimulatory factors, both of which are essential to present antigens from APCs to naïve T or B cells to elicit antigen-specific effector T or B cells.
ref:
https://t.cn/A6YRU2vH#
https://t.cn/A6YRU2vT
体测同样不止需要一双鞋，361°飚速专业体测跑鞋矩阵闪亮登场！飚速3PRO全面升级！据说5月份才上的飚速Future也已经引发学生群体的火热关注？跑步媒体！跑圈达人！体考状元！北京体育大学和上海体育大学教师！还有国家冠军！全民关注中考体育，让孩子们选鞋穿！选好鞋穿！#飚速出绩##金榜题名 ##越走文化##361°飚速3pro#
✋热门推荐