#临床肝胆病杂志#
【急性肝衰竭患者中性粒细胞外菌网的产生与不良预后相关】
急性肝衰竭(ALF)以凝血纤溶系统和全身炎症发生显著变化为特点。中性粒细胞外菌网(NETs)的形成与免疫介导和血栓性疾病有关，其激活的中性粒细胞释放其DNA、组蛋白和颗粒酶，如髓过氧化物酶(MPO)。笔者假设ALF患者的NETs的形成能促进疾病的进展。
在2011年~2018年从美国急性肝衰竭研究组登记处招募了共676例ALF(INR≥1.5)或严重急性肝损伤(INR≥2.0)的患者,其中308名患者(45.6%)是由对乙酰氨基酚诱导的ALF。在入院后21天内，483名患者(71.5%)未行肝移植而存活。在入院时获得的血浆样本中测量游离DNA和NET特异性标记物MPO-DNA复合物的水平，并与健康对照组进行对比。此外,对20名ALF患者肝移植时获得的肝组织进行NETs染色。
ALF患者的游离DNA水平比健康对照组高7倍，MPO-DNA复合物水平高2.5倍，正如各种实验室和临床参数所反映的，游离DNA水平与21天无移植生存率无关，但在入院时病情更严重的患者中，游离DNA的水平更高。死亡或紧急需要肝移植的ALF患者中血浆MPO-DNA复合物水平高出入院后21天内未接受肝移植患者30%。在18例可评价的ALF患者的肝组织中有12例患者的NETs染色呈阳性。
因此，笔者在ALF患者中为NET的形成提供了证据。在 ALF患者中升高的血浆MPO-DNA复合物水平与不良预后有关，这表明NET的形成能促进疾病进展。
摘译自： von Meijenfeldt FA, Stravitz RT, Zhang J, et al. Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.Hepatology. 2021 Sep 25. doi: 10.1002/hep.32174.
吉林大学第一医院 李腊梅 牛俊奇 报道
更多国外期刊导读请点击：https://t.cn/A6IlZlbg
【急性肝衰竭患者中性粒细胞外菌网的产生与不良预后相关】
急性肝衰竭(ALF)以凝血纤溶系统和全身炎症发生显著变化为特点。中性粒细胞外菌网(NETs)的形成与免疫介导和血栓性疾病有关，其激活的中性粒细胞释放其DNA、组蛋白和颗粒酶，如髓过氧化物酶(MPO)。笔者假设ALF患者的NETs的形成能促进疾病的进展。
在2011年~2018年从美国急性肝衰竭研究组登记处招募了共676例ALF(INR≥1.5)或严重急性肝损伤(INR≥2.0)的患者,其中308名患者(45.6%)是由对乙酰氨基酚诱导的ALF。在入院后21天内，483名患者(71.5%)未行肝移植而存活。在入院时获得的血浆样本中测量游离DNA和NET特异性标记物MPO-DNA复合物的水平，并与健康对照组进行对比。此外,对20名ALF患者肝移植时获得的肝组织进行NETs染色。
ALF患者的游离DNA水平比健康对照组高7倍，MPO-DNA复合物水平高2.5倍，正如各种实验室和临床参数所反映的，游离DNA水平与21天无移植生存率无关，但在入院时病情更严重的患者中，游离DNA的水平更高。死亡或紧急需要肝移植的ALF患者中血浆MPO-DNA复合物水平高出入院后21天内未接受肝移植患者30%。在18例可评价的ALF患者的肝组织中有12例患者的NETs染色呈阳性。
因此，笔者在ALF患者中为NET的形成提供了证据。在 ALF患者中升高的血浆MPO-DNA复合物水平与不良预后有关，这表明NET的形成能促进疾病进展。
摘译自： von Meijenfeldt FA, Stravitz RT, Zhang J, et al. Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.Hepatology. 2021 Sep 25. doi: 10.1002/hep.32174.
吉林大学第一医院 李腊梅 牛俊奇 报道
更多国外期刊导读请点击：https://t.cn/A6IlZlbg
Israeli Army, Settlers Attack Palestinians in Masafer Yatta
Several Palestinians, including a three-year-old child, were injured during a Jewish colonial settler attack in the Masafer Yatta area on Tuesday night.
Scores of Jewish colonial settlers, under the protection of Israeli occupation army soldiers, broke into several communities in the Masafer Yatta area, south of Hebron (Al-Khalil), in the southern occupied West Bank.
Colonial settlers attacked Palestinian residents and their homes, damaging several vehicles and solar panels, destroying crops, and uprooting dozens of trees.
Palestinian residents fended off the brutal attack, which resulted in the injury of several people, including a child who sustained bruises in the head and back. One of the injured was transferred to the hospital for medical treatment.
Israeli occupation forces joined in on the attack, firing tear gas canisters and stun grenades towards Palestinian residents and their homes, causing dozens to suffocate.
Two elderly men aged 62 and 75 were detained by the Israeli occupation army during the attacks.
https://t.cn/A6MVQwEO
Several Palestinians, including a three-year-old child, were injured during a Jewish colonial settler attack in the Masafer Yatta area on Tuesday night.
Scores of Jewish colonial settlers, under the protection of Israeli occupation army soldiers, broke into several communities in the Masafer Yatta area, south of Hebron (Al-Khalil), in the southern occupied West Bank.
Colonial settlers attacked Palestinian residents and their homes, damaging several vehicles and solar panels, destroying crops, and uprooting dozens of trees.
Palestinian residents fended off the brutal attack, which resulted in the injury of several people, including a child who sustained bruises in the head and back. One of the injured was transferred to the hospital for medical treatment.
Israeli occupation forces joined in on the attack, firing tear gas canisters and stun grenades towards Palestinian residents and their homes, causing dozens to suffocate.
Two elderly men aged 62 and 75 were detained by the Israeli occupation army during the attacks.
https://t.cn/A6MVQwEO
托法替布治疗大动脉炎
参考文献：Kong X, Sun Y, Dai X,et al. Treatment efficacy and safety of tofacitinib versus methotrexate in Takayasu arteritis: a prospective observational study[J]. Ann Rheum Dis. 2021 Aug 6:annrheumdis-2021-220832. doi: 10.1136/annrheumdis-2021-220832. Epub ahead of print. PMID: 34362744.
参考文献：Kong X, Sun Y, Dai X,et al. Treatment efficacy and safety of tofacitinib versus methotrexate in Takayasu arteritis: a prospective observational study[J]. Ann Rheum Dis. 2021 Aug 6:annrheumdis-2021-220832. doi: 10.1136/annrheumdis-2021-220832. Epub ahead of print. PMID: 34362744.
✋热门推荐